M2 — Nicotiana attenuata

Summary

A4A49_26094, designated NaM2 in coyote tobacco (Nicotiana attenuata) on scaffold01424, encodes a cyclophilin-type peptidyl-prolyl cis-trans isomerase (PPIase) with EC 5.2.1.8 activity. The gene is associated with diverse molecular functions including GTP:GDP antiporter activity, U5 and U2 snRNA binding, L-serine O-acetyltransferase activity, cyclosporin A binding, peroxidase activity, salicylic acid binding, histone and chromatin binding, and protein tagging. It is linked to biological processes such as nicotine metabolism, protein proline isomerization, alternative mRNA splicing via the spliceosome, cysteine anabolism, the MEP pathway, and responses to chlorate and sulfate starvation. Localization evidence connects the product to the Golgi stack, thylakoid lumen, stromule, secretory vesicle, and catalytic step 2 spliceosome. Associations with agronomically relevant traits include leaf length, sucrose content, jasmonic acid content, photosynthetic rate, respiration rate, temperature stress response, herbicide sensitivity, root hair length, and chloroplast development. Related genes in other species link the family to water stress tolerance, cold stress response, hydrotropism, phototropism, embryo patterning, and cell polarity.