NPK1 — Nicotiana attenuata

Summary

A4A49_06877 (NPK1) on chromosome 1 of coyote tobacco (Nicotiana attenuata) encodes a plant MAPKKK family protein with serine/threonine and tyrosine kinase activity, and is annotated with MAPKK and MEKK activity. The gene is associated with the MAPK cascade, cytokinesis, cell plate assembly, and regulation of cytokinesis, as well as with cell cycle phases including mitosis, meiosis, prophase, metaphase, anaphase, and interphase. It is linked to lateral growth, DNA replication and anabolism, and pheromone response. The encoded protein localises to the nucleus, cytoplasm, nucleolus, plasmalemma, cortical microtubule, and microtubule-organising centre. NPK1 is also associated with drought tolerance. Studies of related genes in other species link the family to protein kinase domain-containing proteins and EC numbers 2.7.11.34, 2.7.11.21, 2.7.12.2, 2.7.11.25, and 2.7.11.1.