TOP3B — Medicago truncatula

Summary

MTR_3G084800, designated TOP3B on chromosome 3 of barrel medic (Medicago truncatula), encodes a type I topoisomerase with DNA binding, metal binding, and zinc binding activities, containing TOPRIM and Topo_IA domains. This gene is associated with DNA topological change, DNA replication, recombination, and repair, as well as chromatin modeling, cell cycle, cell division, and both programmed and necrotic cell death. It is linked to ribosome biogenesis, response to copper, and localizes to the nucleus and the RecQ helicase-Topo III complex. Related genes in other species connect the family to DNA metabolism and topoisomerase activity (EC 5.6.2.1).