FLS — Medicago truncatula

Summary

MTR_3G072820, designated MtFLS, encodes a flavonol synthase, a 2-oxoglutarate-dependent dioxygenase that also exhibits leucocyanidin oxygenase, flavanone 3-dioxygenase, naringenin-chalcone synthase, and dihydroflavanol 4-reductase activities. The gene is associated with flavonol and anthocyanin biosynthesis, regulation of phenylpropanoid metabolism, and coumarin anabolism. It has been linked to responses to UV-B, jasmonic acid, oxidative stress, wounding, gravity, and molecules of fungal origin, as well as auxin polar transport and nodulation. Associations with traits include anthocyanin content, photosynthetic ability, UV light sensitivity, herbicide sensitivity, insect damage response, flower development, pollen fertility restoration, root morphology, stomatal closure, and abiotic stress responses such as drought, salt, and low temperature tolerance. The protein localises to the cytosol, nucleus, endoplasmic reticulum, and tonoplast. Studies of related genes in other species link the family to flavonol synthesis, root gravitropic response, and cyst nematode resistance.