HMA1 — Lactuca sativa

Summary

LsHMA1, encoded by the gene LSAT_V11C600316910 on chromosome 6 of garden lettuce (Lactuca sativa), is a P-type ATPase of the IB subfamily with heavy-metal-associated domains. It has been annotated with copper, zinc, and cadmium transporting ATPase activities, as well as histone methylase activity. The gene is associated with detoxification of zinc, copper, and cadmium ions, copper and zinc ion homeostasis and transport, response to cobalt and toxic substances, and regulation of root morphogenesis. It has been linked to traits including copper sensitivity, drought tolerance, high temperature stress response, oxidative stress response, bacterial disease response, leaf senescence, flowering time, plant height, root length, and stomatal opening and closure. Studies of related genes in other species connect the family to chloroplast copper delivery, photosensitivity under high light, and the water-water cycle of photosynthesis.