HMA1 — Lactuca sativa

Summary

LsHMA1, encoded by the gene LSAT_V11C600301450 on lettuce chromosome 6, is a P-type ATPase with a heavy-metal-associated domain, annotated with copper, zinc, and cadmium transporting ATPase activities as well as histone methylase activity. In lettuce, it is associated with detoxification of zinc, copper, and cadmium ions, copper and zinc ion homeostasis and transport, response to cobalt and toxic substances, regulation of root morphogenesis, and the photosynthetic electron transport chain. The gene product localises to the chloroplast thylakoid membrane, chloroplast envelope, vacuolar membrane, and other endomembrane compartments. Associations include drought tolerance, high temperature stress response, oxidative stress response, disease tolerance, leaf senescence, flowering time, plant height, root length, germination rate, and nitrate uptake. Studies of related genes in other species link the family to copper transport, heavy metal tolerance, and photosynthetic electron transport.