GRF3 — Lactuca sativa

Summary

LsGRF3 (GRF3) on chromosome 6 of garden lettuce encodes a Growth-Regulating Factor (GRF) protein containing QLQ and WRC domains, and is annotated as a transcription coactivator with ATP and protein binding activities. It localises to the nucleus and is associated with responses to deep water, gibberellin, and cold, as well as cell population proliferation, cell cycle regulation, adaxial/abaxial pattern specification, root meristem growth, seed development, and cell division. The gene has been linked to numerous traits including seed weight, leaf shape, water use efficiency, anthocyanin content, root oxidative activity, and floral organ development. Associations also include phosphate acquisition, resistance to Plum pox virus, and leaf cell proliferation. Related genes in other species have been linked to organ size, seed size, leaf cell size, and regeneration efficiency.