HMA4 — Lactuca sativa

Summary

LSAT_V11C300150190, symbol HMA4, on garden lettuce (Lactuca sativa) chromosome 3, encodes a P-type ATPase with a transducin domain A superfamily fold, annotated as a copper transporter with ATP hydrolase and copper-binding activities. The gene is associated with detoxification of copper ions, copper ion homeostasis, response to toxic substances, cadmium transport, and membrane transport. Its product localises to the vacuolar membrane, plasmalemma, and general membrane. HMA4 is associated with root length and plant height. Related genes in other species, linked by sequence similarity, connect the family to the EC classes 7.2.2.8 and 7.2.2.-.