M2 — Lactuca sativa

Summary

LsM2 (LSAT_V11C100045460) on chromosome 1 of garden lettuce encodes a cyclophilin-type peptidyl-prolyl cis-trans isomerase (PPIase) with cis-trans proline isomerase activity and cyclosporin A binding capability. The gene is associated with protein folding, regulation of protein refolding, and responses to abscisic acid, salt, and mannitol. It is linked to sesquiterpenoid metabolism, lactone anabolism, and sporopollenin biosynthesis. The product localizes to the chloroplast stroma, cytosol, plasma membrane, cytoplasm, and nucleus. LsM2 is also associated with heterosis. Related genes in other species link the family to peptidyl-prolyl isomerase activity (EC 5.2.1.8).