ERD8 — Hordeum vulgare subsp. vulgare

Summary

HORVU.MOREX.R3.5HG0490180 (HvERD8) on barley chromosome 5H encodes a heat shock protein 90 (HSP90) family member with ATP-dependent protein folding chaperone activity, transcription regulator activity, and multiple binding functions including LRR domain, preprotein, siRNA, miRNA, and blue light photoreceptor activity. The gene is associated with diverse biological processes such as cellular response to brassinosteroid stimulus, auxin metabolism, UV protection, gene silencing by miRNA, and circadian clock photoentrainment. It localizes to the chloroplast outer membrane, ER lumen, proteasome, and secretory vesicles. HvERD8 is associated with maturity time, stem rust response, drought sensitivity, seed viability, herbicide sensitivity, zinc sensitivity, aphid response, and downy mildew resistance. Studies of related genes in other species connect the HSP90 family to heat shock response, pathogen resistance, floral transition, and male fertility.