HSP70 — Hordeum vulgare subsp. vulgare

Summary

HORVU.MOREX.R3.4HG0387570 (HSP70) on barley chromosome 4H encodes a heat shock protein 70 family chaperone with ATP hydrolase activity and ATP binding, and is annotated as an ATP-dependent protein folding chaperone that also binds heat shock proteins. The gene is associated with protein folding in the endoplasmic reticulum, protein refolding, the ERAD pathway, and the ER unfolded protein response. It is linked to responses to heat, stress, viruses, and immune and innate immunity processes, as well as lipid metabolism and response to thirst. The product localises to the ER chaperone complex, ER lumen, chloroplast membrane, tonoplast, membrane, cytoplasm, nucleus, and axonemal central pair projection. Studies of related genes in other species link this gene family to similar stress and protein quality control functions.