CDC2 — Daucus carota subsp. sativus

Summary

DCAR_017892 (CDC2) on carrot chromosome 5 encodes a protein with serine/threonine kinase activity, CDK activity, and RNA polymerase II CTD heptapeptide repeat kinase activity, and it binds cyclin and ATP. The protein belongs to the CLK kinase family and contains a protein kinase domain. CDC2 is associated with cell cycle control, including mitotic G2/M transition, G1/S transition, mitosis, S phase, interphase, and regulation of mitotic entry, as well as meiotic cell cycle modulation. It is linked to dedifferentiation, DNA damage response, intracellular signal transduction, regulation of gene expression, photoperiodism, inflorescence development, and flower development. The protein localizes to the nucleus, cytoplasm, cytosol, spindle, CDK holoenzyme, and casein kinase II complex. Studies of related genes in other species link the family to additional kinase activities.