CDC2 — Daucus carota subsp. sativus

Summary

DCAR_016445, designated CDC2 on carrot chromosome 5, encodes a dual-specificity kinase (EC 2.7.12.1) with cyclin-binding, RNA polymerase II CTD heptapeptide repeat kinase, and CDK activity. The product belongs to the CLK kinase family and possesses serine/threonine kinase and ATP-binding domains. In carrot, CDC2 is associated with cell cycle control, including G1/S and G2/M transitions, mitosis, S phase, interphase, and meiotic cell cycle modulation. It is also linked to dedifferentiation, response to wounding and UV-C, intracellular signal transduction, and cell division. The protein localises to the nucleus, cytoplasm, spindle, and CDK holoenzyme complex. Studies of related genes in other species connect the family to additional mitogen-activated protein kinase activities (EC 2.7.11.22–24), though these associations are not yet established in carrot.