M2 — Daucus carota subsp. sativus

Summary

DCAR_015912 (DcM2) on carrot chromosome 4 encodes a cyclophilin-type peptidyl-prolyl cis-trans isomerase (PPIase) with cyclosporin A binding activity. The protein localises to the chloroplast stroma, cytosol, plasma membrane and nucleus. In carrot, DcM2 is associated with protein folding, regulation of protein refolding, and responses to abscisic acid, salt and mannitol, as well as activation of the salinity response. It has also been connected to carotenoid anabolism and sensitization. Studies of related cyclophilin genes in other species link the family to general PPIase activity (EC 5.2.1.8).