TK — Cucumis sativus

Summary

CsTK (CSA_6G110310) in cucumber (Cucumis sativus, chromosome 6) encodes a thymidine kinase with thymidine kinase activity (EC 2.7.1.21), belonging to the thymidine kinase family and containing a P-loop NTPase domain. The enzyme binds ATP, metal ions, and identical proteins, and is associated with thymidine metabolism, DNA anabolism, double-strand break repair, homologous recombination, and responses to UV-C, cold, and stress. It is linked to seed germination, seedling development, and electron transfer, and localizes to the cytoplasm. Associations include sucrose content, net photosynthetic rate, transpiration rate, stomatal resistance, and germination rate. The gene is also connected to chloroplast development, cpDNA replication, and genotoxic stress tolerance. Studies of related genes in other species link the family to chloroplast biogenesis, genome integrity, and organellar DNA damage tolerance.