CAM2 — Cucumis melo

Summary

MELO3C004375.2, designated CmCAM2 on melon chromosome 6, encodes a protein containing EF-hand calcium-binding domains. The gene product is associated with monoatomic ion channel activity, protein domain specific binding, and numerous other molecular functions including auxin efflux transporter activity and MAPKK activity. CmCAM2 is linked to a wide range of biological processes, including the GABA shunt, cellular detoxification, regulation of defense response by callose deposition, gene silencing by miRNA, and response to molecules of oomycete origin. The gene is associated with traits such as bacterial blight disease resistance, viral disease response, aphid response, fruit shape, seed viability, heat tolerance, osmotic response sensitivity, and days to flowering. Localization evidence places the product at the endosome membrane, microtubule, chloroplast envelope, plant-type cell wall, and endoplasmic reticulum. Studies of related genes in other species link the family to calcium homeostasis, thermotolerance, freezing tolerance, basal defense, and herbivore resistance.