HPR3 — Capsicum annuum

Summary

CaHPR3 (T459_01304) on pepper chromosome 1 encodes a protein with D-isomer 2-hydroxyacid dehydrogenase catalytic and NAD(P)-binding domains. It has multiple annotated enzyme activities, including glyoxylate reductase (NADH), glycerate dehydrogenase (NAD+), hydroxypyruvate reductase (NADPH), formate dehydrogenase (NAD+), (2R)-hydroxyphenylpyruvate reductase [NAD(P)H], hydroxypyruvate reductase [NAD(P)H], D-lactate dehydrogenase (NAD+), glyoxylate reductase (NADPH), and oxidoreductase activity acting on the CH-OH group of donors with NAD or NADP as acceptor, as well as NAD binding. CaHPR3 is associated with formate breakdown, the oxidative photosynthetic carbon pathway, fatty acid metabolism, and photorespiration. It localises to mitochondria, chloroplasts, and the cytosol. The gene is linked to carotenoid content. Studies of related genes in other species link the HPR3 family to flavonoid content and to EC numbers 1.1.1.28, 1.1.1.29, 1.1.1.26, and 1.1.1.110.