HPR3 — Capsicum annuum

Summary

CaHPR3 (T459_01306) on pepper chromosome 1 encodes a glyoxylate/hydroxypyruvate reductase HPR3, a D-isomer 2-hydroxyacid dehydrogenase with NAD(P)-binding domains. The enzyme exhibits glyoxylate reductase, hydroxypyruvate reductase, glycerate dehydrogenase, formate dehydrogenase, and D-lactate dehydrogenase activities. CaHPR3 is associated with photorespiration, the oxidative photosynthetic carbon pathway, formate breakdown, and fatty acid metabolism. The protein localises to mitochondria and cytosol. It has been connected to carotenoid content. Studies of related genes in other species link the HPR3 family to flavonoid content and to EC numbers 1.1.1.28 (D-lactate dehydrogenase), 1.1.1.29 (glycerate dehydrogenase), 1.1.1.26 (glyoxylate reductase), and 1.17.1.9 (formate dehydrogenase).