AXE1 — Arabidopsis thaliana

Summary

AT5G63110 (AXE1/HDA6) on chromosome 5 of Arabidopsis thaliana encodes a histone deacetylase 6, a member of the HDAC_I/II family with NAD-independent histone deacetylase activity, histone demethylase activity, transcription corepressor activity, and chromatin binding. It is associated with drought stress tolerance, ABA sensitivity, promoter silencing, and mRNA polyadenylation. The gene is linked to transposable element silencing, RNAi-like chromatin silencing, negative regulation of seed maturation, floral organ abscission, and fruit abscission. It localizes to the PRC2 complex, Sin3-type complex, HDAC complex, and nucleolus. Associations include grain size, floral organ length, flower abscission zone morphology, plant female sterility, branch angle, potassium content and sensitivity, leaf necrosis, hybrid incompatibility, and brassinosteroid content. Studies of related genes in other species link the family to meiotic recombination, disease tolerance, and soluble solid content.