FLS2 — Arabidopsis thaliana

Summary

AT5G63580, known as FLS2 (flavonol synthase 2) on Arabidopsis thaliana chromosome 5, encodes a 2-oxoglutarate-dependent dioxygenase with flavonol synthase, flavanone 3-dioxygenase, dihydroflavanol 4-reductase, flavanone 4-reductase and naringenin-chalcone synthase activities. The gene is associated with flavonol and anthocyanin biosynthesis, chalcone anabolism, regulation of phenylpropanoid and anthocyanin metabolism, systemic acquired resistance, auxin polar transport, root meristem growth, endocytosis, and responses to gravity, UV-B, and jasmonic acid. The protein localises to the cytosol, nucleus, endoplasmic reticulum, and tonoplast. FLS2 is linked to traits including flavonoid and anthocyanin content, photosynthetic rate, inflorescence height, UV light sensitivity, herbicide sensitivity, insect damage response, root morphology, and salt, drought, and low-temperature stress tolerance. Studies of related genes in other species connect the family to bacterial disease resistance and flagellin-triggered immunity.