APG7 — Arabidopsis thaliana

Summary

AT5G45900, also known as APG7, ATG7, or PEUP4, encodes an autophagy-related protein 7 (Atg7) with ubiquitin, protein, and zinc binding activities. This gene is associated with macroautophagy, microautophagy, mitophagy, ER-phagy, lipophagy, aggrephagy, and pexophagy. It is linked to protein lipidation, peroxisome fission, chlorophyll a breakdown, and vesicle formation. Phenotypically, ATG7 has been associated with seed yield, biomass, heat resistance, pathogen tolerance, and autophagic flux. The protein localizes to the cytoplasm and vacuole. Additional associations include leaf senescence, pollen fertility, sulfonylurea herbicide sensitivity, submergence tolerance, oxidative stress response, and traits related to root development, stomatal function, and chloroplast development.