RPS4 — Arabidopsis thaliana

Summary

AT5G45250 (RPS4) in Arabidopsis thaliana encodes a disease resistance protein containing TIR, NB-ARC, and leucine-rich repeat domains, annotated with ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase and lipase activities, as well as DNA-binding transcription factor activity. The gene is associated with bacterial wilt resistance, resistance to Pseudomonas syringae and Ralstonia solanacearum, effector-triggered immunity, and systemic acquired resistance mediated by salicylic acid signaling. It is linked to defence response to Gram-negative bacteria, hypersensitive cell death, and programmed cell death. RPS4 is also associated with leaf abscission, shade avoidance, floral organ development, response to hypoxia and singlet oxygen, and regulation of hydrogen peroxide metabolism. The protein localises to the nucleus, cytoplasm, membrane, and endomembrane system. Associations with biomass yield, seed yield, lignin content, root thickness, and stomatal resistance have been noted.