STM — Arabidopsis thaliana

Summary

AT4G37930 (SHM1, also known as SHMT1) encodes a serine hydroxymethyltransferase (EC 2.1.2.1) with glycine hydroxymethyltransferase activity, a pyridoxal phosphate-dependent enzyme. The gene is associated with regulation of photorespiration, glycine metabolism, L-serine metabolism, tetrahydrofolate interconversion, and one-carbon metabolism. It is linked to shoot and root meristem development, floral whorl morphogenesis, internode patterning, phyllotaxy, leaf shape, stem thickness, fruit growth and development, and photosynthetic rate. Associations also include responses to abiotic stress (drought, salt, high light, cadmium, zinc), biotic stress (basal defense against Pseudomonas syringae), stomatal closure, leaf senescence, and copper and iron concentration. The protein localizes to chloroplast stroma, thylakoid, and envelope, as well as mitochondrial lumen and the respiratory chain complex I.