HA1 — Arabidopsis thaliana

Summary

AT2G18960 (HA1, also known as AHA1, OST2) encodes a P-type ATPase (EC 7.1.2.1) with cation-transporting, proton-transporting, and P-type ATPase activities, along with additional annotated molecular functions including transmembrane signaling receptor, guanylyl cyclase, and calmodulin binding activities. In Arabidopsis, HA1 is associated with embryo development, aluminum resistance, and plasma membrane H+-ATPase activity. The gene is linked to diverse biological processes including proton export across the plasma membrane, membrane polarization, acid secretion, nitrate import, vacuolar acidification, and responses to pH, drought, salinity, and abscisic acid signaling. Associations extend to traits such as water use efficiency, photosynthetic rate, aluminum and manganese sensitivity, iron and calcium concentration, nitrate and phosphorus uptake, lateral root length, cell elongation, leaf temperature, turgor pressure, bacterial disease response, and high temperature stress response. The protein localizes to the plasma membrane, tonoplast, ER, nuclear envelope, and other cellular compartments.