FVE — Arabidopsis thaliana

Summary

AT2G19520, also known as FVE, MSI4, or NFC4, encodes a WD40 repeat-containing protein with histone-binding domains, belonging to the RBAP46/RBAP48/MSI1 family. The gene product is associated with diverse molecular functions including histone methylase and deacetylase activities, chromatin and damaged DNA binding, and ubiquitin-protein transferase activity. FVE is linked to numerous biological processes such as transposable element silencing, telomere maintenance, DNA damage repair, meiotic recombination, and regulation of photosynthesis and photomorphogenesis. It localizes to multiple cellular compartments including the PRC2 and HDAC complexes, nucleolus, chloroplast envelope, and plasmodesmata. The gene has been connected to traits including flowering time, seed viability, plant size, shoot branching, carpel number, and responses to nitrate starvation, phosphorus, and UV light. Studies of related genes in other species link the family to pericentromeric CHG methylation.