NIM1 — Arabidopsis thaliana

Summary

AT1G64280 (NIM1, also known as NPR1) encodes a transcriptional co-regulator with salicylic acid binding, calmodulin binding, and oxidoreductase activity acting on a sulfur group of donors with disulfide as acceptor. It contains BTB/POZ, ankyrin repeat, and NPR1/NIM1-like C-terminal domains. In Arabidopsis, NIM1 is associated with salicylic-acid-mediated immune response, systemic acquired acclimation to high light stress, and resistance to numerous pathogens including Pseudomonas syringae, Fusarium head blight, powdery mildew, bacterial blight, and Huanglongbing. It is also linked to hybrid seed viability, plant height, salt and drought stress sensitivity, and callose synthesis. The protein localizes to the nucleus, cytosol, plasmodesma, and stress granules, and participates in hormone signaling pathways. Studies of related genes in other species link the NPR1 family to resistance against biotrophic pathogens, root-knot nematodes, and oxidative stress tolerance.