PDR8 — Arabidopsis thaliana

Summary

AT1G59870 (PDR8, also known as ABCG36 and PEN3) encodes an ATP-binding cassette (ABC) transporter of the pleiotropic drug resistance subfamily, annotated with activities including auxin efflux, cadmium ion transmembrane transport, and efflux permease activity. In Arabidopsis, the gene is associated with nonhost resistance, heavy metal resistance, drought resistance, hypersensitive response, and cell death regulation. It is linked to diverse biological processes such as exosome biogenesis, glucosinolate breakdown, oxygen metabolism, and activation of brassinosteroid-mediated signalling. The encoded protein localises to the ER membrane, stress granules, and the trans-Golgi network. Associations with agronomic traits include grain dormancy, germination ratio, sodium and potassium content, cell membrane stability, shoot fresh weight, root hair length, auxin content, and days to flowering. Studies of related genes in other species link the family to plant immunity and pathogen resistance.