ABA2 — Arabidopsis thaliana

Summary

AT1G52340 (ABA2) encodes a xanthoxin dehydrogenase (EC 1.1.1.288) of the short-chain dehydrogenase/reductase family, catalysing a key step in abscisic acid (ABA) biosynthesis. The gene is associated with ABA deficiency, reduced seed dormancy, wilty phenotypes under drought, and increased water loss. It has been linked to sugar and glucose sensitivity, pathogen resistance including powdery mildew and Botrytis cinerea, and cucumber mosaic virus accumulation. Associations extend to stomatal closure and response to humidity, leaf expansion, seed size, anthocyanin accumulation, and endosperm cellularization. The product localises to the cytosol, nucleus, mitochondria, and stress granules, and is connected to ABA biosynthesis and mediated signalling pathways. Studies of related short-chain dehydrogenase/reductase family members in other species link the family to disease resistance and abiotic stress responses.