MYCGR3G46840 — Zymoseptoria tritici

Summary

CMR3 (MYCGR3G46840) on chromosome 8 of Zymoseptoria tritici encodes a C2H2-type zinc-finger transcription factor of the Ste12 family. The protein localises to the nucleus, cytosol and chromatin, and binds sequence-specific DNA to regulate RNA polymerase II transcription. CMR3 is associated with mating behaviour, sexual reproduction (sporocarp development), pseudohyphal and filamentous growth, parasexual conjugation, and phenotypic switching. It is linked to cellular responses to nutrients and calcium ions, upregulation of oxidative stress responses, and downregulation of transcription. The gene has been connected to immune evasion, development of the symbiont in the host, regulation of secondary metabolite biosynthesis, biofilm formation, and galactose metabolism. Studies of related genes in other species link the Ste12 family to loss of pathogenicity and oxidative stress responses.