MYCGR3G39405 — Zymoseptoria tritici

Summary

MYCGR3G39405 (symbol sidI) on Zymoseptoria tritici chromosome 3 encodes a protein with oxalate-CoA ligase, medium-chain fatty acid-CoA ligase, fatty acid synthase, ketoacyl-ACP synthase, CoA-ligase, ligase, redox, and ATP hydrolase activities, and phosphopantetheine and ATP binding. The gene is associated with the biosynthesis of ferricrocin, fumonisin, N',N'',N'''-triacetylfusarinine C, polyketides, flavonoids, ergosterol, and other toxins, as well as acetyl-CoA and fatty acid metabolism. It is linked to cellular responses to hydrogen peroxide and iron ion starvation. The encoded protein localises to the peroxisome (lumen and membrane) and cytosol. Studies of related genes in other species link the sidI family to loss of pathogenicity and reduced virulence, though this has not been established in Z. tritici. The gene is also related to SID4 and contains AMP-binding and ANL_N_sf domains.