MYCGR3G10621 — Zymoseptoria tritici

Summary

MYCGR3G10621, symbol ago1, on Zymoseptoria tritici chromosome 11, encodes an Argonaute-family protein with endoribonuclease activity that cleaves siRNA-paired mRNA and binds siRNA and ssRNA. The gene is associated with RNA interference pathways including siRNA-mediated post-transcriptional gene silencing, RNAi-mediated chromatin silencing, and heterochromatin assembly at centromeres. It is linked to cell cycle regulation, including maintenance of G0 phase and cell cycle checkpoint control, as well as nitrogen utilization. The product localizes to the RITS and ARC complexes, heterochromatin islands, subtelomeric and centric heterochromatin, the mating-type region, cytoplasm, and nucleus. Related genes in other species link the family to similar RNA silencing and chromatin regulation functions.