PMIT1 — Triticum aestivum

Summary

TRAESCS5A02G072200, designated PMIT1 and also known as TaNRAMP2, encodes a member of the NRAMP family of metal ion transporters. The gene product possesses manganese and metal ion transmembrane transporter activity and is localized to the tonoplast, vacuolar membrane, trans-Golgi network membrane, and plasmalemma. PMIT1 is associated with the transport and homeostasis of manganese, iron, and cadmium, as well as with detoxification, phytochelatin anabolism, phenylpropanoid anabolism, sucrose metabolism, and positive regulation of the ROS metabolic process. In bread wheat, the gene has been linked to cadmium accumulation and uptake. Associations with agronomically important traits include grain zinc and iron content, grain protein content, grain yield, plant height, root length, root fresh weight, root volume, manganese sensitivity, and lodging degree. Studies of related genes in other species connect it to manganese deficiency tolerance and cadmium tolerance.