GAD — Sorghum bicolor

Summary

SORBI_3006G096500 (SbGAD2) encodes a glutamate decarboxylase (EC 4.1.1.15) with pyridoxal phosphate-dependent decarboxylase and transferase domains, exhibiting glutamate decarboxylase, sphinganine-1-phosphate aldolase, pyridoxal phosphate binding, and calmodulin binding activities. The gene is associated with glutamate and sphingolipid breakdown, carboxylic acid metabolism, and GABA formation. It localizes to the ER membrane, ER, and cytosol. SbGAD2 is linked to grain yield and drought tolerance. Studies of the rice relative OsGAD2 connect the family to grain, seed, root, and shoot phenotypes, as well as dwarfism and sterility. Sequence similarity links the family to sugar content, growth stage, germination rate, and salt tolerance traits.