CYTME2 — Sorghum bicolor

Summary

SORBI_3003G280900 (symbol CYTME2, also known as SbNADP-ME) on sorghum chromosome 3 encodes a malic enzyme with malate dehydrogenase (decarboxylating) activity (EC 1.1.1.40), capable of using NADP+ or NAD+ and binding metal ions. The protein belongs to the malic enzyme family and is associated with C4 photosynthesis, malate metabolism and transport, the oxidative pentose pathway, auxin and brassinosteroid signaling, and detoxification. It is linked to drought tolerance, water use efficiency, photosynthetic rate, respiration rate, stomatal resistance, and brassinosteroid sensitivity. Associations also include aluminum tolerance, osmotic stress tolerance, salt response, seed germination, root development, flowering time, pathogen resistance, and leaf vascular pattern formation. The protein is localized to multiple compartments including the cytosol, plastid, mitochondria, apoplast, and plasmodesma. Studies of related genes in other species link the family to growth, primary metabolism, and salt stress tolerance.