ADH — Sorghum bicolor

Summary

SORBI_3002G379100 (SbADH) on sorghum chromosome 2 encodes a protein with ADH-like_N and ADH-like_C domains, a GroES-like superfamily domain, and a NAD(P)-binding domain superfamily. It has S-(hydroxymethyl)glutathione dehydrogenase (NAD+, NADP+, and NAD(P)+) activity, S-nitrosoglutathione reductase (NADH) activity, aldo-keto reductase (NAD) activity, redox activity, calcium ion binding, protein homodimerization activity, zinc binding, and protein binding. The gene is associated with responses to hypoxia, flooding, hydrogen peroxide, heat acclimation, sucrose, estradiol and caffeine, as well as methanal metabolism, cellular respiration, programmed cell death, seed development, cell wall modification, and osmotic and salinity responses. It has been linked to traits including stem thickness, plant height, photosynthetic and respiration rates, leaf senescence, drought tolerance, herbicide sensitivity, low temperature stress, disease tolerance and salt tolerance. The product localises to the cytosol, nucleus, plastid, mitochondria and plasma membrane. Studies of related genes in other species connect the family to submergence, waterlogging, hypoxia, cold, salt and drought tolerance, aldehyde detoxification, fermentation, lateral root initiation and stomatal closure.