CYP51 — Sorghum bicolor

Summary

SORBI_3002G154900, designated CYP51 on sorghum chromosome 2, encodes a cytochrome P450 monooxygenase with sterol 14-demethylase activity (EC 1.14.14.154) and additional annotated functions including brassinolide synthase, beta-amyrin 28-monooxygenase, tabersonine 16-hydroxylase, abscisic acid 8'-hydroxylase, and flavonoid 3'-monooxygenase activities. The protein localises to the endoplasmic reticulum membrane and is associated with sterol and brassinosteroid biosynthesis and homeostasis, abscisic acid metabolism and breakdown, indole alkaloid and flavonoid anabolism, saponin anabolism, demethylation, fruit ripening, response to light stimulus, response to abscisic acid, and response to thirst. Related genes in other species link the family to additional oxidoreductase activities, including EC 1.14.14.180, 1.14.14.179, and 1.14.14.126.