M2 — Solanum tuberosum

Summary

StM2 (PGSC0003DMG400030445) on potato chromosome 6 encodes a cyclophilin-type peptidyl-prolyl cis-trans isomerase (PPIase, EC 5.2.1.8) that binds cyclosporin A and exhibits cis-trans proline isomerase activity. The gene is associated with protein folding and refolding regulation, wound healing, protein secretion, and responses to abscisic acid, salt, and mannitol. It has been connected to phenylpropanoid, fatty acid, and lipid metabolism, virus-induced post-transcriptional gene silencing, nitric oxide storage, activation of salinity response, and cell growth. The product localises to the chloroplast stroma, cytosol, plasmalemma, cytoplasm, and nucleus. StM2 is also linked to the SALTTL trait. Studies of related cyclophilins in other species place the family in broader stress and developmental contexts, though these roles are not yet established for potato.