M2 — Solanum tuberosum

Summary

PGSC0003DMG400001630, designated M2 or CYP on potato chromosome 1, encodes a cyclophilin-type peptidyl-prolyl cis-trans isomerase (EC 5.2.1.8) with additional annotated molecular functions including cyclosporin A binding, salicylic acid binding, histone binding, and peroxidase activity. The gene is associated with diverse biological processes such as protein proline isomerization, chaperone-mediated protein complex assembly, alternative mRNA splicing, response to light intensity, wound healing, and regulation of ARF protein signal transduction. It is linked to numerous agronomically relevant traits including starch content, sucrose content, photosynthetic rate, respiration rate, temperature stress response, herbicide sensitivity, zinc sensitivity, and variegated leaf. The encoded protein localizes to multiple cellular compartments including the thylakoid lumen, Golgi stack, and secretory vesicle. Studies of related cyclophilin family members in other species connect this gene family to drought response, cold stress tolerance, hydrotropism, and embryo patterning.