FLS2 — Solanum lycopersicum

Summary

SlFLS2, the tomato FLS2 gene on chromosome 2, encodes a protein with leucine-rich repeat domains, a serine/threonine kinase active site, and a protein kinase domain. The product possesses transmembrane receptor protein serine/threonine kinase activity, signaling receptor activity, and protein serine/threonine kinase activity, and it binds ATP, steroids, and SNAREs. SlFLS2 is associated with activation of immune response, PTI signalling, the MAPK cascade, and membrane fission, and it has been connected to bacterial disease response, stomatal resistance, and self-incompatibility. The protein localises to the plasma membrane, endosome, ER membrane, and nucleus. Studies of related genes in other species link the family to non-specific serine/threonine protein kinase activity (EC 2.7.11.1).