CDC2 — Pisum sativum

Summary

PSAT1G164200 (symbol CDC2) on garden pea chromosome 1LG6 encodes a cyclin-dependent kinase (CDK) with protein serine/threonine kinase activity, RNA polymerase II CTD heptapeptide repeat kinase activity, and cyclin binding, classified as EC 2.7.11.22. The gene is associated with cell cycle control, including G1/S and G2/M transitions, mitosis, meiotic cell cycle modulation, S phase, and regulation of mitotic entry. It is also linked to cell division, regulation of growth, signal transduction, translation elongation, protein synthesis, rRNA processing, and regulation of gene expression. The product localizes to the nucleus, cytoplasm, CDK holoenzyme, and NRD complex. Pathways involve CDKA:CycD complex formation and inactivation, E2F:DP complex activation, and G1/S transition. Studies of related genes in other species further connect the family to CDK activity.