FRD1 — Phaseolus vulgaris

Summary

PHAVU_008G060100, designated PvFRD1, encodes a protein with iron chelate reductase activity, also associated with NAD(P)H oxidase H2O2-forming and peroxidase activities and calcium ion binding. The protein contains Fe3_Rdtase_TM_dom, Fe_red_NAD-bd_6, FAD-bd_8, FAD-bd_FR_type, and FNR_nucleotide-bd domains. PvFRD1 is associated with siderophore-iron import, multicellular organismal iron ion homeostasis, response to bacteria, and general homeostasis. It localises to the plasmalemma and nucleus. The gene is linked to photosynthetic rate and numerous phenotypes including iron acquisition, deficiency tolerance and response, chilling tolerance, iron concentration and uptake, metal ion homeostasis, gold bioreduction, disease resistance, root growth under iron deficiency, mitochondrial iron transport, uranium response, and iron reduction. Related genes in other species link the family to iron metabolism and chlorophyll content.