RACK1 — Phaseolus vulgaris

Summary

PHAVU_002G327500, designated PvRACK1, encodes a RACK1-like protein containing WD40 repeat domains. The gene product exhibits ADP-glucose pyrophosphatase, ADP-ribose pyrophosphatase, NAD+ diphosphatase, and nucleoside diphosphatase activities, along with MAP kinase scaffold activity, translation regulator activity, and binding functions including siRNA, miRNA, PKC, and phosphatase binding. PvRACK1 is associated with diverse biological processes such as positive regulation of ethylene biosynthesis, meristem initiation, root system development, leaf pattern formation, pri-miRNA processing, and gene silencing by miRNA. It localizes to the cytosolic ribosome, heterotrimeric G-protein complex, nuclear speck, and preprophase band. The gene is linked to numerous agronomic traits including photoperiod sensitivity, vegetative to reproductive phase transition, seed viability, submergence tolerance, aluminum response, phosphorus uptake, viral disease response, and starch mobilization. Studies of related genes in other species connect the RACK1 family to immune response, MAP kinase signaling, shoot development, meristem activity, drought and salt stress resistance, and miRNA activity.