NSH1 — Phaseolus vulgaris

Summary

PHAVU_001G188700, designated PvNSH1 (also known as PvURH1) on French bean chromosome 1, encodes a protein with an inosine/uridine hydrolase domain and exhibits xanthosine nucleotidase, adenosine nucleosidase, purine nucleosidase, uridine hydrolase, and inosine nucleosidase activities. The product also shows protein heterodimerization, identical protein binding, and homodimerization activity. PvNSH1 is associated with nucleotide salvage, uridine breakdown, ureide anabolism, ribonucleoside and purine nucleoside breakdown, and seedling development, and localizes to the cytosol. The gene has been connected to purine and pyrimidine catabolism, nucleoside metabolism, uridine degradation, seedling growth, leaf senescence, and general senescence. Studies of related genes in other species link the family to inosine and xanthosine accumulation and to stem and leaf senescence traits.