PMIT1 — Oryza sativa Japonica

Summary

OsPMIT1 (OS01G0503400) on rice chromosome 1 encodes a member of the NRAMP family of metal ion transporters, with molecular functions including manganese, iron, aluminium, and cadmium ion transmembrane transporter activity. The gene is associated with multiple metal transport and homeostasis processes, including manganese, iron, cadmium, and aluminium transport, as well as cellular responses to these metals. In rice, the NRAMP5 variant has been linked to cadmium accumulation in shoots and grain, grain cadmium content, grain quality, yield, and root and xylem development. NRAMP1 has been linked to broad-spectrum disease resistance, immunity, iron uptake, and reactive oxygen species metabolism, while NRAMP6 is associated with resistance and growth. The encoded protein localises to the plasma membrane, vacuole, endosome, and plasmodesmata. Related genes in other species link the family to vacuolar iron transport, iron mobilisation, and pathogen resistance.