RGA5 — Oryza sativa Indica Group

Summary

BGIOSGA036370 (symbol RGA5, also known as OiPI-TA or PI-TA) on chromosome 12 of indica rice encodes a thioredoxin domain-containing protein with NB-ARC, LRR, and other disease-resistance protein domains. It binds ADP, ATP, and metal ions. The gene is associated with the regulation of pattern recognition receptor signaling, innate immune response-activating signaling, antiviral and antibacterial defense responses, and hypersensitive response programmed cell death. Its product localizes to the cytosol, cytoplasm, and plasmalemma. RGA5 is linked to blast resistance (particularly the PI1 phenotype) and to grain weight traits including TGRWT and GRWT. Studies of related genes in other species connect the family to defense responses, blast disease, stripe rust, amylose content, and grain yield.