NIM1 — Nicotiana attenuata

Summary

A4A49_40277 (NIM1/NPR1) in coyote tobacco (Nicotiana attenuata) encodes a protein with NPR1/NIM1-like C-terminal, BTB/POZ, and ankyrin repeat domains, annotated as a transcriptional co-regulator with salicylic acid binding, oxidoreductase, calmodulin binding, and DNA-binding activities. It is associated with regulation of systemic acquired resistance, defense responses to insects and herbivores, salicylic acid biosynthesis and signaling, response to microbial phytotoxin, and nucleoside anabolism. The gene is linked to traits including drought tolerance, herbivore resistance, bacterial blight disease resistance, leaf necrosis, and responses to jasmonic acid, ethylene, and nitrogen. It localizes to the nucleus, cytosol, plasmodesma, and stress granules. Studies of related genes in other species link the family to pathogen resistance, systemic acquired acclimation, and oxidative stress tolerance.