M2 — Nicotiana attenuata

Summary

A4A49_27145, designated NaM2 in coyote tobacco (Nicotiana attenuata) on scaffold00055, encodes a cyclophilin-type peptidyl-prolyl cis-trans isomerase (EC 5.2.1.8) with cyclosporin A binding and cis-trans proline isomerase activity. The gene is associated with nicotine metabolism, the methylerythritol phosphate (MEP) pathway, isoprenoid anabolism, demethylation, detoxification, and secondary metabolism. It is linked to protein folding, regulation of protein refolding, excretion, signal transduction, and responses to abscisic acid, salt, and mannitol. Associations also include cell growth, seed germination, and leaf development. The product localises to the chloroplast stroma, cytosol, cytoplasm, nucleus, and plasmalemma. Additionally, NaM2 is linked to leaf length, root length, protein content, and salt tolerance. Related genes in other species place the family in general protein folding and stress responses.