ATR2 — Nicotiana attenuata

Summary

ATR2 (MYC2) on coyote tobacco chromosome 10 encodes a bHLH transcription factor of the MYC/MYB_N family, with annotated molecular functions including transcription factor binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding, and transcription corepressor and coactivator activities. In this species, ATR2 is associated with nicotine and phenolamide biosynthesis, and with biological processes such as superoxide metabolism, induced systemic resistance via ethylene signaling, regulation of defense response to insects, and positive regulation of seed maturation. The gene is linked to numerous traits including anther length, petal length, seed protein content, chilling stress response, submergence tolerance, shoot elongation, and root epidermal cell length. It localizes to the nuclear ubiquitin ligase complex, mediator complex, plasmodesmata, and Golgi. Studies of related genes in other species associate the family with saline-alkali tolerance, chilling tolerance, drought tolerance, seed maturation, glandular trichome formation, and resistance to Botrytis cinerea and bacterial pathogens.