SHD — Nicotiana attenuata

Summary

A4A49_14181 (symbol SHD, also known as HSC80) on coyote tobacco chromosome 6 encodes a heat shock protein 90 family chaperone with ATP-dependent protein folding activity. The gene is associated with diverse molecular functions including DNA polymerase activity, transcription regulator activity, and telomeric repeat binding. It has been linked to biological processes such as viral translation, cellular response to unfolded protein, double-strand break repair, and defense response involving respiratory burst. Localization evidence connects the product to the chloroplast outer membrane, ER lumen, and plasma membrane. The gene is associated with numerous traits including seed set percent, submergence tolerance, bacterial and viral disease responses, temperature stress response, aphid response, floral organ morphology, and reproductive growth time. Studies of related genes in other species link the family to thermotolerance, broad-spectrum disease resistance, and salinity tolerance.