HMG1 — Medicago truncatula

Summary

MTR_5G087550, designated HMG1 (also known as HMGR1), encodes a hydroxymethylglutaryl-CoA reductase (NADPH) in barrel medic (Medicago truncatula) on chromosome 5. This enzyme is associated with the mevalonate pathway and is linked to isoprenoid, sterol, triterpenoid, and saponin anabolism, as well as CoA metabolism. The gene has been associated with organogenesis, lateral root and root development, nodulation, and responses to jasmonic acid and absence of light. It is associated with leaf necrosis, flower morphology and color, senescence, fertility, male gametophyte development, plant growth, and seed phytosterol content. The encoded protein localizes to plastid, peroxisome, mitochondrial, chloroplast, and ER membranes. Studies of related genes in other species link the family to mevalonate pathway regulation, phytosterol content, and plant development.